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NCOH PhD projects cycle 2018: Complex Systems

Rationale for the research theme 'Complex Systems'

The spread of infectious diseases is characterized by dependency between potential hosts (human and animal), whereby non-linear patterns emerge. These patterns are influenced by the characteristics of human/animal, such as network structures and properties of the pathogen (e.g. host specificity). The rapidly growing availability of "big (omics) data" provides opportunities to better understand interactions between host and pathogen, but traditional analytical methods are not sufficient. A better understanding of complex systems can contribute to better prediction of the evolution of a particular problem, enabling earlier and more effective prevention measures.

All awarded projects - together with all previously-allocated NCOH projects - have been thematically clustered into three overarching Research Topics; i.e.:

  • Complex systems & gene flows & metagenomics
  • Prophylactic vaccines & new therapeutics
  • Vector-borne diseases

The programmes for the Research Topics will be available soon.

Projects

Project #1

Staphylococcus aureus infection dynamics in cattle

Research topic: Prophylactic vaccines & new therapeutics

PhD student: to be appointed

Project #2

Innovative antibody-based strategies to combat future emergence of zoonotic viral infections.

Research topic: Prophylactic vaccines & new therapeutics

PhD student: to be appointed

Project #3

Improving the functional activity of monoclonal antibodies against Gram-negative bacteria.

Research topic: Prophylactic vaccines & new therapeutics

PhD student: to be appointed

Project #4

BRICK study- Bacteriophage Research on Immune response, Clinical use and Knowledge on virome changes.

Research topic: Prophylactic vaccines & new therapeutics

PhD student: to be appointed

Project #5

Development of Bayesian Inference Methods for Estimating Transmission Trees for Antibiotic-Resistant Pathogens in Hospitals and Farms.

Research topic: Complex systems

PhD student: to be appointed

Project #6

Gene flow networks in animals, the food chain and the environment.

Research topic: Complex systems

PhD student: to be appointed

Project #7

Antimicrobial resistance in relation to the persistence of antimicrobial residues after treatment of farm animal: input for risk management (RESRISK).

Research topic: Complex systems

PhD student: to be appointed

Project #9

How the virome of vector mosquitoes affects pathogen transmission.

Research topic: Vector-borne disease

PhD student: to be appointed

Project #8

Towards circular livestock farming practices.

Research topic: Complex systems

PhD student: to be appointed

Project #10

Accelerating drug development against emerging vector-borne viruses.

Research topic: Vector-borne disease

PhD student: to be appointed