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NCOH PhD projects cycle 2017: Metagenomics

Rationale for the research theme 'metagenomics'

Recent technological developments now allow large-scale, in-depth (and affordable) investigation of microbial populations and communities at the molecular level. Microbial interactions, within hosts, between hosts and between populations, are a fundamental aspect in the societal problems addressed in the four research themes of the Netherlands Centre for One Health. Metagenomics was therefore chosen as the overarching theme for the first 8 PhD tracks of the NCOH, with the explicit task to create – where possible – new interdisciplinary, inter-thematic, and inter-institutional research collaborations.

Coordinator theme metagenomics: Marc Bonten, UMC Utrecht.

Projects

Project #1

Host-microbe interactions as elicitors of cryptic antibiotics in actinomycetes and spread of antimicrobial resistance under low antibiotic stress

PhD student: Doris van Bergeijk

Project #2

Molecular mechanisms of microbiota-mediated colonization resistance against intestinal outgrowth of multidrug-resistant Enterobacteriaceae (E. coli, K. pneumoniae) and enterococci.

PhD student: Paul Stege

Project #3

Mechanisms of microbiota-mediated defence against various infectious diseases.

PhD student: Quinten Ducarmon

Project #4

Microbiome fortification for healthier pigs through metagenomics-driven culturomics and microbial bioactive metabolite discovery.

PhD student: Simen Fredrikesen

Project #5

Metagenomic analysis of animal, environmental and human microbiomes in the context of excess pneumonia risk around livestock production farms in the Netherlands: effects in humans.

PhD student: Warner van Kersen

Project #6

Metagenomic analysis of animal, environmental and human microbiomes in the context of excess pneumonia risk around livestock production farms in the Netherlands: flow of microorganisms.

PhD student: to be appointed (linked to project project 5)

Project #7

CoCoNod (Coma, Convulsions and Nodding Syndrome): aetiology, risk factors and outcome of paediatric neuroemergencies in resource poor settings.

PhD student: Arthur Edridge

Project #8

Immunological, microbiological and pharmacological aspects of invasive fungal infections.

PhD student: Nico Janssen