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Antibiotic persister and biofilm-associated infections: Investigating the role of the host microenvironment to optimize antibiotic therapy

Timeline

2017 - 2021

Group and collaboration

Dr. Alireza Mashaghi – Leiden University
PhD student: Maik Kok

Project description

The work in the laboratory of Dr. Alireza Mashaghi (LACDR/Leiden University) is focused on the use of biophysical and bioengineering approaches to understanding host immunity. We use state-of-the-art technologies including organ-on-chips, optical tweezers and acoustic force spectroscopy to study the crosstalk between immune signaling (e.g., involved in macrophage response), mechanics, metabolism and intra-cellular stress response machinery (the chaperone network).

Tasks

  • Study the implications of cellular and tissue mechanics for infection and septic shock
  • Study the implication of cellular metabolism for defense against pathogens
  • Study the implications of heat shock response for host-pathogen interactions and antibiotic resistance

Disease Intervention Strategies is the overarching theme for more than 10 PhD tracks in NCOH projects to create new interdisciplinary, inter-thematic, and inter-institutional research collaborations.