Home » Research » PhD Research Programme » Complex systems & Metagenomics » CANVAS – Broadly protective glycoconjugate vaccines targeting major animal and zoonotic Gram-positive pathogens

CANVAS – Broadly protective glycoconjugate vaccines targeting major animal and zoonotic Gram-positive pathogens

Timeline

September 2019 - September 2023

Group and collaboration

Collaboration: Dr. Lindert Benedictus & Dr. Gerrit Koop (co-promotors, Utrecht University), Prof. Dr. Arjan Stegeman & Prof. Dr. Victor Rutten (promotors, Utrecht University)

PhD Student: Kitty Exel

Project description

The main objectives of this project are to characterise the contribution of colonisation of cattle with S. aureus to the spread of S. aureus and the occurrence of intramammary infections and to determine how colonisation shapes the adaptive immune response against S. aureus. Within this project a multi-disciplinary approach will be used to address the main objective. First, a cost effectiveness analysis will help to analyse the potential impact of implementing different intervention strategies for the different S. aureus strains. Next, transmission of S. aureus within and between cows will be characterised in detail using molecular genotyping methods. Profiling of S. aureus specific immunity combined with characterisation of colonisation will elucidate how colonisation shapes immunity against S. aureus. Finally, the role of antibody response against wall teichoic acid, a dominant variable cell wall antigen of S. aureus, will be characterised in vitro and ex vivo.


Complex Systems & Metagenomics is the overarching theme for more than 10 PhD tracks in NCOH projects to create new interdisciplinary, inter-thematic, and inter-institutional research collaborations.

PhD student interview

Interview: ‘Bacteria fascinate me: they are tiny but have enormous impact’

Many studies focus on health and disease from a human, animal or environmental perspective. Kitty Exel realised during her studies that it is important to adopt an integrated approach. “This is why I am excited to study the bacterium Staphylococcus aureus, which infects both cattle and humans.”

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