This is the fifth interview with the PhD students of the Metagenomics projects in a series of 8 background articles. Keep following this website for the next interview in this series.
Interview with Simen Fredriksen, PhD candidate of the project ‘Microbiome fortification for healthier pigs through metagenomics-driven culturomics and microbial bioactive metabolite discovery’.
I chose to do a PhD in metagenomics due to having an interest in microbial ecology as well as a more general interest in science. The work I do is similar to what I did as a master student at the University of Oslo, so I knew what I was signing up for. I find microbiome research interesting in part due to it being a relatively new and fast developing field that still has many unanswered questions. Apart from the academic side, I am happy to be working on a project that has concrete goals towards improving animal and human health.
The ultimate goal of my project is to reduce the prevalence of infectious disease in pig farms. As antimicrobials have been widely used to prevent and treat infections (some of which have zoonotic potential), antimicrobial resistance has emerged. Thus, my project also impacts on the health of humans and the global one health. Methodically, my project is centered around integrating sequencing technology and bioinformatics with culturing of bacteria and other microbiological methods. Most importantly, I utilize metagenomics to detect genetic markers associated with healthy and diseased animals. These markers can be used to identify members of the microbiota which can antagonize pathogens as well as previously unknown synergies between co-infecting organisms.
The most challenging part of my position is acquiring metagenomics samples from diseased farm animals, as the window of time between the observation of relevant symptoms and antibiotic treatment can be small. Additionally, it is not always straightforward to identify what disease a pig is suffering from. The most enjoyable part of my position is working with bioinformatics on large datasets. It is also nice to be conducting multidisciplinary science in collaboration with researchers from a range of different universities and countries. Similarly, I find it important to interact with veterinarians and other members of the pig farming industry in order to properly understand my study system.
In January 2016, NCOH’s own bilingual Twitter account, @ncohnl, was registered. With investigators in the field of one health as a primary target group, via this Twitter account relevant developments in the context of one health are highlighted.
During the Q fever outbreak from 2007-2010, an unprecedented number of people became infected with the Q fever bacterium Coxiella burnetii. Of all patients who die of chronic Q fever, 55 percent died within one year of diagnosis.
With great pleasure, we invite you to the Annual Scientific Meeting of the Netherlands Centre for One Health (NCOH) with ‘Complex Systems’ as main theme. This Annual Scientific Meeting will be held in Nijmegen on 17 May 2019.
Leading scientists Jeremy Farrar, Marion Koopmans, and Ron Fouchier will take you into the world of new infectious diseases outbreaks and show you how we can prepare for these outbreaks.