This is the fourth interview with the PhD students of the Metagenomics projects in a series of 8 background articles. Keep following this website for the next interview in this series.
Interview with Doris van Bergeijk, PhD student of the project ‘The effect of host-microbe interactions on the secondary metabolism of actinomycetes’ at Leiden University (Institute of Biology Leiden).
‘My interest in antibiotic research started during a microbiology course in the second year of my bachelor. We had to test bacteria from the sewage against different antibiotics and I was shocked by their multi-drug resistance. To me it was clear that we were in need of new antibiotics (or alternatives) and I am very excited that I am now working on a project that will hopefully contribute to the discovery of new antibiotics.’
‘Actinomycetes are filamentous bacteria that are well known for their antibiotic production. Sequencing has shown that the genomes of actinomycetes contain a wealth of undiscovered biosynthetic gene clusters and this discovery has spiked research into this direction. Signals from the host/environment of these bacteria might influence the expression of these clusters. I aim to find host-specific signals, for example stress hormones, that can influence the antibiotic production with the ultimate goal to use actinomycetes to control microbial infections.’
‘So far, I have discovered that certain signaling molecules indeed influence the antibiotic production of actinomycetes. I now aim to identify the biosynthetic gene clusters that respond to these hormones and the corresponding metabolites. Additionally, I have had the unique opportunity to isolate and sequence actinomycetes from mammoth stool. This data, together with the metagenomics data of the gut microbiome of the mammoth, allows us to study bacteria from the past and analyse the biosynthetic gene clusters that are present. Hopefully this can give us insight in the way these genes have developed over time and what role actinomycetes can play in the protection of higher organisms.’
Six leading researchers received the NWO Spinoza Prize and the Stevin Prize today from Ingrid van Engelshoven, Minister of Education, Culture and Science. The prizes are the highest distinctions in Dutch science. Cell biologist Anna Akhmanova, biophysicist Marileen Dogterom, social psychologist Carsten de Dreu, historian Beatrice de Graaf, virologist Marion Koopmans and microbiologist John van...
On 28 May, the RIVM published a report on the current state of knowledge about bacteriophages. The RIVM study was commissioned by the Ministry of Health, Welfare and Sport after publications in the media about phage therapy. Since the television broadcast Dokters van Morgen, microbiologist Marc Bonten of the UMC Utrecht is regularly confronted with...
The Netherlands Antibiotic Development Platform (NADP) launched a novel funding opportunity during the NADP Voucher Event on 22 May 2018. The NADP Vouchers will support researchers and small- or medium-sized enterprises to bring their novel antibiotics and alternatives a step closer to the clinic.
On 22 February, an international symposium was organized on the possibilities of phage therapy in the treatment of patients with infections due to resistant bacteria.