This is the fourth interview with the PhD students of the Metagenomics projects in a series of 8 background articles. Keep following this website for the next interview in this series.
Interview with Doris van Bergeijk, PhD student of the project ‘The effect of host-microbe interactions on the secondary metabolism of actinomycetes’ at Leiden University (Institute of Biology Leiden).
‘My interest in antibiotic research started during a microbiology course in the second year of my bachelor. We had to test bacteria from the sewage against different antibiotics and I was shocked by their multi-drug resistance. To me it was clear that we were in need of new antibiotics (or alternatives) and I am very excited that I am now working on a project that will hopefully contribute to the discovery of new antibiotics.’
‘Actinomycetes are filamentous bacteria that are well known for their antibiotic production. Sequencing has shown that the genomes of actinomycetes contain a wealth of undiscovered biosynthetic gene clusters and this discovery has spiked research into this direction. Signals from the host/environment of these bacteria might influence the expression of these clusters. I aim to find host-specific signals, for example stress hormones, that can influence the antibiotic production with the ultimate goal to use actinomycetes to control microbial infections.’
‘So far, I have discovered that certain signaling molecules indeed influence the antibiotic production of actinomycetes. I now aim to identify the biosynthetic gene clusters that respond to these hormones and the corresponding metabolites. Additionally, I have had the unique opportunity to isolate and sequence actinomycetes from mammoth stool. This data, together with the metagenomics data of the gut microbiome of the mammoth, allows us to study bacteria from the past and analyse the biosynthetic gene clusters that are present. Hopefully this can give us insight in the way these genes have developed over time and what role actinomycetes can play in the protection of higher organisms.’
It’s time for an update! You and all NCOH scientists are invited to join the NCOH Science Café on 29 October 2019 to get up to speed with the latest developments, meet fellow NCOH colleagues, and establish new collaborations. Feel free to inform your fellow researchers and PhD students about the Science Café, they will...
Researchers from the National Institute for Public Health and the Environment, Utrecht University, University Medical Center Utrecht, the Animal Health Service and Wageningen Bioveterinary Research, all members of the ESBLAT consortium, have previously shown that ESBL antimicrobial resistance is common in humans, livestock and companion animals, food of animal origin and the environment. However, ESBL...
The Netherlands Centre for One Health (NCOH) was allocated a budget of two million euro Public-Private Partnership (PPP) Allowance to organise and realise their first PPP call. This call involves strategic partnerships under the Knowledge and Innovation Agenda of Top Sector Life Sciences & Health (LSH): One Health call.
The number of bacteria that are resistant to antibiotics is increasing globally. In the Netherlands this number remains fairly stable and is lower than in many other countries. Nevertheless, there is still cause for concern and caution. This is evident from the annual report NethMap/MARAN 2019 in which various organisations jointly present data on antibiotic...