This is the sixth interview with the PhD students of the Complex Systems & Metagenomics projects in a series of background articles. Keep following this website for the next interview in this series.
Interview with Kirsty Kwok, PhD student of the project ‘Metagenomic analysis of animal, environmental and human microbiomes in the context of excess pneumonia risk around livestock production farms in the Netherlands: flow of microorganisms’ at the Department of Viroscience, Erasmusmc.
‘During 2007-2010, there was a huge Q-fever outbreak with more than four thousand cases in the Netherlands, that was originated from dairy goat and sheep farms. Further investigation of infectious disease at animal-human interface is warranted. Follow-up epidemiological studies observed an excess pneumonia risk in residents living close to farms, however the mechanisms behind remain unknown.’
‘Advances of Next-Generation Sequencing (NGS) has opened more applications in the infectious disease field. I first learnt about Next-Generation Sequencing (NGS) when I was doing my MPhil in Hong Kong about norovirus surveillance and molecular epidemiology. I was then fascinated by the power of metagenomics sequencing (mNGS) in the context of infectious disease diagnostics, that allows pathogen detection without having prior knowledge or pre-defined targets. What’s more, mNGS also made high-throughput virome/microbiome profiling possible.’
‘Here, we aim to utilize mNGS to characterize livestock, environmental and human virome so as to untangle the mechanism of excess pneumonia risk around livestock production farms in the Netherlands. We also aim to reconstruct the virome flow between livestock, farm environments and residents who live near farms, which would potentially guide zoonotic infectious disease preparedness in a One Health context. Currently, I am conducting a systematic review on viral metagenomics study of farm animals to identify potential baseline virome profiles of farm animals to guide our project.’
Another NCOH year of exciting and important research. It’s time for an update! You and all NCOH scientists are invited to join this year’s NCOH Science Café on 29 October 29 in Utrecht to get up to speed with the latest developments and meet fellow NCOH colleagues. Prevention and control of infectious diseases outbreaks are...
Researchers from the National Institute for Public Health and the Environment, Utrecht University, University Medical Center Utrecht, the Animal Health Service and Wageningen Bioveterinary Research, all members of the ESBLAT consortium, have previously shown that ESBL antimicrobial resistance is common in humans, livestock and companion animals, food of animal origin and the environment. However, ESBL...
The Netherlands Centre for One Health (NCOH) was allocated a budget of two million euro Public-Private Partnership (PPP) Allowance to organise and realise their first PPP call. This call involves strategic partnerships under the Knowledge and Innovation Agenda of Top Sector Life Sciences & Health (LSH): One Health call.
The number of bacteria that are resistant to antibiotics is increasing globally. In the Netherlands this number remains fairly stable and is lower than in many other countries. Nevertheless, there is still cause for concern and caution. This is evident from the annual report NethMap/MARAN 2019 in which various organisations jointly present data on antibiotic...